Recombinant Dystroglycan anticorps

N° du produit ABIN7543384

Cet anticorps anti-Dystroglycan est un anticorps Lapin Chimeric détectant Dystroglycan dans ELISA et FACS. Adapté pour Humain.

Aperçu rapide pour Recombinant Dystroglycan anticorps (ABIN7543384)

Antigène: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp Dystroglycan est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Clone: P38G1

Détail du produit anti-Dystroglycan anticorps

Fonction: Anti-Beta Dystroglycan [P38G1], Rabbit IgG, kappa

Specificité: This antibody recognizes human and mouse beta dystroglycan (β-DAG). Beta-dystroglycan is a transmembrane protein that plays an important role in connecting the extracellular matrix to the cytoskeleton. It plays an important role in linking dystrophin to the laminin-binding alpha-dystroglycan. It acts as a cell adhesion receptor in both muscle and non-muscle tissues. It also functions in cell adhesion-mediated signaling and implicated in cell polarity.

Réactivité croisée: Souris

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing BALB/c mice with a mixture of transfected HEK 293 cells expressing human and mouse beta-DAG.

Isotype: IgG kappa

Information d'application

Indications d'application: The binding specificity of this antibody to human and mouse beta dystroglycan expressed on the surface of CHO cells was confirmed using ELISA and flow cytometry. The binding affinity of the original IgG antibody to human beta dystroglycan was determined to be 941 pM. This antibody was used in combination with anti-Laminin antibody PL60B3 for the generation of a bispecific antibody (CN113651891).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur Dystroglycan

Antigène: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Autre désignation: Beta Dystroglycan

Sujet: Dystroglycan 1, Dag1, Beta-DG, β-DAG, BETA DAG, Dystroglycan, Dystrophin-associated glycoprotein 1, B-Dystroglycan, B Dystroglycan, Beta-dystroglycan, β dystroglycan, β-dystroglycan

UniProt: Q14118, Q62165

Pathways: Maintenance of Protein Location, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus